Prostaglandins, Leukotrienes and Essential Fatty Acids
نویسنده
چکیده
Disturbances in fatty acid (FA) metabolism may link chronic psychological stress, endocrine responsiveness, and psychopathology. Therefore, lipidmetabolome-wide responses and their relationshipswith endocrine (cortisol, insulin, and adiponectin) responsiveness to acute stress (AS) were assessed in a primate model of chronic social stress (CS). Compared to controls (not exposed to CS), CS increased (Pr0.05) circulating triacylglycerol (TG) and phosphatidylethanolamine (PE) n-6/n-3 and reduced (Pr0.05) cholesterol ester (CE) 16:1n7 and phosphatidylcholine (PC) 18:1n7, suggesting lower omega-3 FA status and stearoyl-CoA desaturase activity, respectively. Cortisol responses to AS positively correlated with TG n-6/n-3 (r1⁄40.93; P1⁄40.007), but only in CS monkeys. The adiponectin response to AS inversely correlatedwith CEn-6/n3 (r1⁄4 0.89; P1⁄40.045) and positivelywith TG16:1n7 (r1⁄40.98; P1⁄40.004), only in CS monkeys. Our results are consistent with previously reported FA profiles in stress-related psychopathology and suggest that compositional changes of specific lipid FAs may form new functional markers of chronic psychological stress. Published by Elsevier Ltd.
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